Information for Healthcare Professionals

Efficacy of FluMist in Children

FluMist demonstrated significant reductions in influenza versus the flu shot in a large head-to-head influenza vaccine trial in children1; 2:*†

FluMist vs. Flu Shot - Overall Efficacy Against Influenza Illness

Matched strains: 52.5% reduction in flu cases vs the flu shot (1.4% vs 2.9%)2
Mismatched strains: 54.2% reduction in flu cases vs the flu shot (3.2% vs 7.1%)2
Overall efficacy: 54.4% reduction in flu cases vs the flu shot (4.5% vs 9.8%)2

* Full study published in The New England Journal of Medicine – February, 2007.
† Study Design: Randomized, double-blind, double-dummy comparison of the relative efficacy of FluMist and TIV intramuscular injection that included children 24 months to 59 months of age, with a 42-day and a 6-month follow-up for safety through the end of the influenza surveillance period for the 2004-2005 influenza season (N=4,166). Vaccine-naïve children in both groups received 2 doses. Comparative efficacy vs culture-confirmed modified CDC influenza-like illness due to matched and mismatched strains [ATP population].
‡ Data is representative of the indicated population; full study population is represented in the Prescribing Information.
§ The attack rates for FluMist vs the flu shot for all strains circulating during the 2004-2005 flu season were as follows: A/New Caledonia (H1N1) (0.0% vs 1.0%), A/Wyoming (H3N2) (0% vs 0%), A/California-like (H3N2) (1.2% vs 4.9%), matched B/Yamagata lineage (1.4% vs 1.9%, NS), and mismatched B/Yamagata lineage and B/Victoria (2.1% vs 2.3%, NS), respectively.

FluMist achieved these significant reductions against matched and mismatched influenza strains:

FluMist vs. Flu Shot - Matched and Mismatched Efficacy Against Influenza Illness

II Data is representative of the indicated population; full study population is represented in the Prescribing Information.
** The attack rates for FluMist vs the flu shot for all matched strains circulating during the 2004-2005 flu season were as follows: A/New Caledonia (H1N1) (0.0% vs 1.0%), A/Wyoming (H3N2) (0% vs 0%), and matched B/Yamagata lineage (1.4% vs 1.9%, NS), respectively.
†† The attack rates for FluMist vs the flu shot for all mismatched strains circulating during the 2004-2005 flu season were as follows: A/California-like (H3N2) (1.2% vs 4.9%), and mismatched B/Yamagata lineage and B/Victoria (2.1% vs 2.3%, NS), respectively.